Combined Mutation of Apc, Kras, and Tgfbr2 Effectively Drives Metastasis of Intestinal Cancer
نویسندگان
چکیده
منابع مشابه
Cancer Stemness in Apc- vs. Apc/KRAS-Driven Intestinal Tumorigenesis
Constitutive activation of the Wnt pathway leads to adenoma formation, an obligatory step towards intestinal cancer. In view of the established role of Wnt in regulating stemness, we attempted the isolation of cancer stem cells (CSCs) from Apc- and Apc/KRAS-mutant intestinal tumours. Whereas CSCs are present in Apc/KRAS tumours, they appear to be very rare (<10(-6)) in the Apc-mutant adenomas. ...
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ژورنال
عنوان ژورنال: Cancer Research
سال: 2017
ISSN: 0008-5472,1538-7445
DOI: 10.1158/0008-5472.can-17-3303